Edgar samson



UNITED STATES PATEN OF NEW YORK, N. Y., ASSIGNOR '10 CARL F. STIEFEL, OF NEW YORK, N.

EDGAR SAMSON,

Brion.

CHEMICAL COMPOUND OF CALCIUM CHLORID AND HEXAMETHYLIENAMIN AND A PROCESS RELATING TO THE SAME.

No Drawing.

To all whom it may concern:

Be it known that I, EDGAR SAMSON, a subject of the King of Great Britain, and resident of the borough of Manhattan, in the city of New York, county and State of New York, have invented a certain new and useful Chemical Compound of Calcium Chlorid and Hexamethylenamin and a Process Relating to the Same, of which the following is a specification.

This invention relates to the general class of therapeutic agents.

Calcium compounds have for sometime past been known to possess specially valuable therapeuticproperties, as systemic antiphlogistics and hemostatics. Among these, calcium chlorid is generally believed to be the most valuable, but its therapeutic use is made difiicult, first, because of the fact that it is strongly hygroscopic, making it technically impossible to produce and maintain it in tablet or other handy form, and,

' secondly, because it is strongly caustic and irritant, and for this reason has to be taken in greatly diluted, and therefore bulky,

form. Hexamethylenamin, on the other hand, has valuable urinary and systemic antiseptic properties, but it is also irritant in the large doses which in case of systemic antisepsis must be given to produce adequate results.

My invention has for its object to provide a a new chemical compound in the form ofja= dry, free-running salt, which is absolutely free from hygroscopic properties, is practically tasteless in the aqueous solution of therapeutic doses, and unites the hemostatic and antiphlogistic properties of calcium chlorid with the antiseptic properties of hexamethylenamin. In this form both drugs can be given in adequate doses, the hexamethylenamin counteracting the disagreeable causticity of the calcium chlorid, and the calcium chlorid tending to'prevent bladder and kidney irritation readily leading to hematuria, which large doses of hexamethylenamin are known to frequently produce.

The following represents a method of pre- Specification of Letters Patent.

Patented Aug. 1, 1916.

Application filed March 13, 1914. Serial No. 824,544.

I paring thiscompound: Molecular quantities of anhydrous calcium chlorid and hexamethylenamin are dissolved separately inthe minimum quantity of water for produc- I 7 is then gradually added tothe saturated hexamethylenamin solution. In order to maintain these solutions in a cool state, the receptacles are cooled .by exterior means, as icing, or its equivalent. By mixing these two solutions, a white crystallized precipitate is obtained, resulting from the combination of one molecular part of calcium chlorid and one molecular part of hexamethylenamin. This crystalline mass or precipitate is then separated by filtration, washed and dried. It is dissolved in alcohol and recrystallized once therefrom, the resulting crystals being an absolutely pure chemical product. The eifect of the dissolving is to dissociate and .ionize these substances as completely as'possible, the dissociated i'ons being believed to react to form the new compound, free 'from water of crystallization. A modification of this method is to intimately mix molecular parts methylenamin, both in powder form, dissolve this mixture in the minimum quantity I of boiling alcohol, from which the chemical compound at once crystallizes upon cooling. The crystallized precipitate is In the second process, by ringing the two substances directly together in dry form and filtered, washed,'and dried, and is then, for the pur- -calcium chlorid and an aquecussolutionof hexamethylenamin, or an alcohohc solut1on l the addition of the alcohol servesto dissolve eachjof these substances, and on their dis-j solving they pound. I In place ofusin unite to for m a' chemical com an aqueous solution of hexamethylenamin, Ican also use advantageously an aqueous vsolution of calcium chlorid'and an alcoholic solution of "hexamethylenamin, or an alcoholic solution of of calcium chlorid and an alcoholic solution of hexamethylenamin; in other-words, the

' test as to what solvent to be used, is, that it should dissolve either substance sufii- .ciently and bring them togetherin a 'diseither substance. [In other words, the sol- 1 vent acts asa vehicle to bring the two sub solved saturated solution under the propor tions before mentioned, and .also the solvent tself must have no chemical action upon I stances together in the closest possible chemical union." From this it will be seenthat any neutral organic or inorganic solvent which will dissolve calcium chlorid on the onehand, and 'hexamethylenamin on the other hand, when these substances are inv the molecularproportions given, will bring about this chemical union, andprovided the concentration of both products is properly chosen, the resulting new chemical product will immediately crystallize.

The resulting chemical compound is readily soluble in water and so stable that its aqueous solution canbeboiled for a con- I siderable period without noticeably liberating formaldehyde.

The chemical compound is'dry, stable, and freerunning and iscapable. of being tableted,.that is, formed into tablets and is so constituted" as to maintain its tablet wform and'not disintegrate by the moisture of chlorid b itself which is stron l w h oscopic, soythat it-is technically in ipo s ible' to produce and maintain it in tablets, as f stated; My. new chemical compound thus 1' affords the advantages of-calcium' chlorid; medication in this exactand convenientv dos-f the air, as is not the case with calcium age form, and hastherefore-this advanta- ,geous characteristic in its usefas anart-iclejof medicine. If thev compound is crystallized-J; ..from-'alcoh0l it? be substantially vfre from water of crystallizatio' percentage of therapeutically POImdii' S increased.

a; White crystallized 'powder-which' jgiyes thecharacteristic chemical. reactions iq f c cium chlorid and those ofhexameth lenamjn,

but does nOtpresent the physical properties I that eb el more, or the prevention and calcium chloride.

substantially free fro :tion,

solventicap able T0 hygroscopic.

no matter which party of the human organtheTair, owing to the fact that it is non,-

.. ".Thequses which readily fsuggest .selveslfor such a compound are, generally 1 calcium chlorid an an aqueous solut on of V "speaking, any condition which. the sys 'temic need forycalcium chloridis indicated, such as all. infiamm'atoryfconditions,

ism they .afi'ect', eczema and other-"irritant. and itching skin diseases,,lobarpneumonia,

asthma hay fever, iritis, etc. and, further:

hemorrhages-prophylaxis of hemorrhage before surgical-operations, internal homer I "rhage, hemoptysis, I .epistaxis, aneurysms post-partum f hemorrhages, indolent an treatment of gastriclulcersi As to the second constituent, I

- hexamethylenamin, this new compound I can be manifestly used in all conditions in whichthe giving of large and continuous doses of hexamethylenamin are desiredandg thereby.

it is of importance to avoid the vesical' andfl renal irritation which would be produced .90 I have described my new compound-,and

several methods of making the samega ej.

I claim as new 1. Asa new article of medicine, the a x I stable and free runnin chemicalcompound: of calcium chlorid .an

in permanent tablet form.' 1 r -hexamethylenamin capable of being tableted and mw t d 1 2. As a new article-"of medicine, acoin-x pound of calcium chloridand hexamethylen? amin, and substantially free, from water- 0f crystallization substantially as described: i 3. A metho of making a newfarticlefof.

medicine, consisting of the. combination of calcium chlorid and hexamethylen-amin substantially free from water of crystallization,

which consists indissolving thesaidcalciumionizing them 'an( l brin'ging together said.

euadfaat armea nd irdissolvingsaid.

non-aqueous solutionsfand crystallizing the chlorid 'and ,said hexamethylenamijn?ina I substantially non-aqueous solvent capable of new article of lia stallizing the I e g.them and recryig. italhz'lngl nd "4 9 5. 4m p 11??? makin alliew article of .medlcme, consisting of t e comb nation of v calcium chlorid and hexaniethylenamin, as my invention, I have signed my name which consists in dissolving the said calcium in presence of two subscribing Witnesses. chlorid and said hexamethylenamin in alcohol, and bringing together said alcoholic EDGAR SAMSON solutions and crystallizing the compound Witnesses: formed thereby. F. Hoe-e,

In testimony, that I claim the foregoing Jos. BISBANO. 

